How can SNPs in non-coding DNA be responsible for disease?

In your study of a new disease in humans you sequence the DNA from effected tissues from 27477 pati Show more In your study of a new disease in humans you sequence the DNA from effected tissues from 27477 patients. I know that is a lot of patients. All the sequencing revealed 5 unique SNPS among your patients with roughly equal numbers of patients possessing each SNP. No diseased patients possessed more than 1 SNP. You had several sets of extended families within your study which indicated indivudals with the disease did pass it on to the next generation. When you examined the SNPs in DNA sequencing data more closely you discovered that none of the 5 SNPs were located in a protein coding gene. How can SNPs in non-coding DNA be responsible for disease? How can you explain 5 unique SNPs all each individually resulting in diease? Show less

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