Would they be higher or lower than in normal cells treated with adrenaline?

When adrenaline binds to adrenergic receptors on the surface of a muscle cell it activates a G prot Show more When adrenaline binds to adrenergic receptors on the surface of a muscle cell it activates a G protein initiating an intracellular signaling pathway in which the activated subunit activates adenylyl cyclase thereby increasing cAMP levels in the cell. The cAMP molecules then activate a cAMP-dependent kinase (PKA) that in turn activates enzymes that result in the breakdown of muscle glycogen thus lowering glycogen levels. You obtain muscle cells that are defective in various components of the signaling pathway. Referring to Figure 1 indicate how glycogen levels would be affected in the presence of adrenaline in the following cells. Would they be higher or lower than in normal cells treated with adrenaline? A. cells that lack adenylyl cyclase B. cells that lack the GPCR C. cells that lack cAMP phosphodiesterase D. cells that have an subunit that cannot hydrolyze GTP but can interact properly with the and subunits Show less

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